Publications by authors named "R Siqueira"
: Triple-negative breast cancer (TNBC) is the most challenging molecular subtype of breast cancer (BC) in clinical practice, associated with a worse prognosis due to limited treatment strategies and its insensitivity to conventional drugs. Zinc is an important trace element for homeostasis, and its Schiff base metal complexes have shown promise in treating advanced tumors. In this study, four new heteroleptic Zn(II) complexes (-) with Schiff bases were synthesized, characterized, and evaluated for their activity in BC cells.
View Article and Find Full Text PDFObjective: To assess the short-term effects of Multiwavelength Photobiomodulation (LumiThera Valeda Light Delivery System) on retinal functional behavior in patients with retinitis pigmentosa (RP).
Materials And Methods: Twelve RP patients (24 eyes) underwent treatment involving nine photobiomodulation (PBM) sessions using the Valeda system, which emits three distinct wavelengths within the yellow (590 nm; 4 mW/cm2), red (660 nm; 65 mW/cm2), and near-infrared (NIR) (850 nm; 0.6 mW/cm2) spectrum.
[Experience of setting up a state pharmacovigilance committee during the COVID-19 pandemicExperiencia de la puesta en marcha de un comité estatal de farmacovigilancia durante la pandemia de COVID-19].
Rev Panam Salud Publica
December 2024
Objective: To describe the implementation and pioneering work of a vaccine pharmacovigilance committee in the state of São Paulo, Brazil, for the analysis of events supposedly attributable to vaccination or immunization (ESAVI) during the COVID-19 pandemic.
Methods: This is a retrospective, mixed-methods (qualitative and quantitative) case study focusing on the work carried out by the pharmacovigilance committee in the years 2021 and 2022. The minutes of committee meetings were used to describe how the committee operates.
Article Synopsis
- The Antarctic climate limits soil formation and the development of ecosystems, leading to most biological activity occurring during the brief summer in ice-free areas, where penguins contribute to nutrient transport through guano.
- This study analyzes the ornithogenic soils of Half Moon Island, focusing on how the island's geology, vegetation, and landforms affect soil characteristics by examining 21 soil profiles collected during the 2014/2015 summer.
- Results show that the soils are mostly Cryosols and Leptosols with high gravel content and varying chemical properties, emphasizing how seabird activity and glacial processes shape soil diversity in Antarctic regions.
Article Synopsis
- Osteoporosis negatively impacts dental implant success, leading to a review focused on how implants integrate with bone in animal models with induced osteoporosis to discover factors that could enhance success rates.
- A thorough database search was conducted for studies published from 2002 to 2023, specifically looking for research on osseointegration in osteoporotic conditions, using strict inclusion and exclusion criteria for animal studies.
- Out of 204 articles screened, 43 studies were selected that examined bone-implant contact (BIC) along with other parameters like bone area and volume, with a risk of bias assessed in the included studies.