Publications by authors named "R Sinharay"
Correction to "Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways".
Sibo Lucas Cheng Michael Hedges Pekka Keski-Rahkonen Anastasia Chrysovalantou Chatziioannou Augustin Scalbert Rudy Sinharay
Environ Sci Technol
October 2024
Article Synopsis
- - This study explored how exposure to high and low levels of air pollution from traffic (TRAP) affects metabolism and gene expression in 50 individuals, including those with chronic lung or heart conditions.
- - Researchers used advanced techniques to analyze blood samples for metabolic and mRNA changes at different times around the exposure, identifying 78 metabolic and 53 mRNA features linked to TRAP, with nitrogen dioxide (NO) being the most significant pollutant.
- - Findings showed that even short-term exposure to TRAP can disrupt physiological functions, particularly influencing gut-related metabolism, with effects that can persist for up to 24 hours after exposure.
Objective: An estimated 250 million people worldwide are chronically infected with hepatitis B virus (HBV), the leading cause of hepatocellular carcinoma (HCC) globally. The novel virus continues to spread at an alarming rate, and with guidance at the onset of the pandemic recommending the deferral of HCC surveillance, the implications on liver cancer care are now emerging and highlight the urgent need for reorganisation of services.
Methods: We analysed how five HCC risk prediction scores could aid stratification of patients with chronic HBV.