Publications by authors named "R Siegemund"
Total Thrombus-Formation System in Patients with Peripheral Artery Disease.
Clin Appl Thromb Hemost
November 2024
Article Synopsis
- The Total Thrombus-formation Analysis System (T-TAS) is an automated tool designed to evaluate thrombus (blood clot) formation under simulated blood flow conditions, particularly in patients receiving antiplatelet therapy.
- This study examined T-TAS's effectiveness in detecting responses to dual antiplatelet therapy (DAPT) among 60 patients with peripheral artery disease (PAD) after a surgical procedure.
- Findings indicated that the platelet-chip (PL-chip) of T-TAS was able to identify low responders to DAPT more effectively than traditional aggregation tests, suggesting it could be a useful tool for monitoring treatment responses in PAD patients.
Weight-adjusted dosing of tinzaparin for thromboprophylaxis in obese medical patients.
Res Pract Thromb Haemost
February 2023
Background: The optimal dose of tinzaparin for prophylaxis in obese medical patients is not well defined.
Objectives: To evaluate the anti-Xa activity in obese medical patients on tinzaparin prophylaxis adjusted for actual bodyweight.
Methods: Patients with a body mass index of ≥30 kg/m treated with 50 IU/kg tinzaparin once daily were prospectively included.
Article Synopsis
- The study evaluated how direct oral anticoagulants (DOACs) affect thrombin generation (TG) in blood, focusing on their plasma levels in newly anticoagulated patients.
- It included 80 patients, monitoring TG and plasma levels of different DOACs (apixaban, edoxaban, rivaroxaban, and dabigatran) over time.
- Results showed that while all DOACs prolonged certain TG parameters, the effects were influenced by patient-specific baseline levels, suggesting that TG tests might provide a better measure of anticoagulation intensity than just measuring drug levels in plasma.