Evaluation of biomedical waste generation in Himachal Pradesh before and during the Covid 19 pandemic.

Himachal Pradesh dealt with the same crisis as other states in India due to the extensive dissemination of the COVID-19 coronavirus infection. Biomedical waste management is crucial for public health and environmental safety, and the pandemic's impact on waste generation is an understudied area. This study specifically utilizes data from the Himachal Pradesh Pollution Control Board as well as information from other governmental and non-governmental organizations, which are analysed and compared for the pre-pandemic and pandemic periods.

Evaluation of the modulatory role of nimodipine in seizures induced by kainic acid and pentylenetetrazole in mice.

The present study aimed at establishing the CD50 and CD99 doses along with complete dose-response profile of two convulsants, namely, kainic acid and pentylenetetrazole (PTZ), in mice and evaluating the modulatory role of the cerebroselective dihydropyridine calcium channel blocker nimodipine. Kainic acid and PTZ were administered intraperitoneally in a dose range of 1-30 mg kg(-1) and 35-75 mg kg(-1), respectively. Nimodipine was administered in graded doses (1-8 mg kg(-1), i.

Anti-seizure efficacy of nimodipine in pentylenetetrazole and kainic acid combined seizure models in mice.

The present study aimed at establishing two models of experimental seizures by combination treatment with subconvulsive doses of PTZ and kainic acid in adult male mice and evaluating the modulatory role of cerebroselective dihydropyridine calcium channel blocker, nimodipine. The CD50 +/- SEM value for PTZ was found to be 20.00 +/- 0.