Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer.

Breast cancer remains a significant global health challenge, with drug resistance and poor bioavailability of chemotherapeutic agents like paclitaxel (PTX) presenting obstacles to effective treatment. This study investigates the potential role of the Solute Carrier Organic Anion Transporter Polypeptide 1A2 (OATP1A2) in PTX transport using computational approaches. We employed computational modeling, molecular docking, and molecular dynamics (MD) simulations to elucidate the structural dynamics of OATP1A2 and its interaction with PTX.

Interplay Between Composition and Cycling Performance of Pre-Lithiated SiO-Si-C Composite Anodes for Lithium-Sulfur Full Cells.

Although silicon-based anodes have been identified as a potential alternative to conventional graphite anodes, the huge volume change (approximately 300%) that occurs in silicon while cycling still impedes this system from practical applications. In the case of silicon-suboxide (SiO)-based anode materials, both LiO and LiSiO are formed during the initial lithiation processes and act as a natural volume buffer matrix to accommodate volume changes and the formation of a stable SEI layer, which improves the cyclability and capacity retention. In this study, a series of SiO/Si/C-based electrodes composed of different amorphous SiO, Si, and graphitic carbon contents were prepared.

Advancing Textile Waste Recycling: Challenges and Opportunities Across Polymer and Non-Polymer Fiber Types.

The growing environmental impact of textile waste, fueled by the rapid rise in global fiber production, underscores the urgent need for sustainable end-of-life solutions. This review explores cutting-edge pathways for textile waste management, spotlighting innovations that reduce reliance on incineration and landfilling while driving material circularity. It highlights advancements in collection, sorting, and pretreatment technologies, as well as both established and emerging recycling methods.

Cornea Oculomics: A Clinical Blueprint for Extending Corneal Diagnostics and Artificial Intelligence in Systemic Health Insights.

Oculomics is an emerging field that leverages ophthalmic imaging data to identify biomarkers of systemic disease, facilitating early diagnosis and risk stratification. Despite its growing recognition, gaps remain in the literature regarding the clinical applications of oculomics. Various systemic diseases-including metabolic disorders (e.

Assessment of the prognostic performance of TIMI, PAMI, CADILLAC and GRACE scores for short-term major adverse cardiovascular events in patients undergoing emergent percutaneous revascularisation: a prospective observational study.

Objectives: Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge. This study aims to assess the effectiveness of four established risk scores in predicting short-term MACE after primary PCI.

Design: Prospective observational study.