Publications by authors named "R Shigemoto"
Article Synopsis
- - The study examines how synaptic changes in neuronal circuits may underlie memory storage, focusing on the structural evidence for synaptic engrams at the hippocampal mossy fiber synapse.
- - Researchers used a combination of chemical potentiation, functional recordings, and advanced microscopy techniques to assess the effects of forskolin on synaptic transmission and structure.
- - Findings revealed that forskolin increased both the number of readily releasable vesicles and their proximity to priming proteins, suggesting that structural reorganization at synaptic sites could correlate with learning and memory processes.
LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K1 Loss and Increased Action Potential Broadening.
Neurol Neuroimmunol Neuroinflamm
September 2024
Article Synopsis
- Autoantibodies against LGI1 are linked to autoimmune encephalitis, impacting the limbic system and causing seizures and memory issues.
- The study focused on how these autoantibodies influence synaptic structure and function, revealing effects on neurotransmitter release.
- Results showed that LGI1 autoantibodies enhanced neurotransmission by increasing release probability but did not affect presynaptic calcium channels; however, they reduced certain potassium channel densities.
Article Synopsis
- AJAP1 is a protein linked to brain diseases and is found in neurons, specifically in dendrites, where it plays a role in recruiting GABA type B receptors (GBRs) to presynaptic sites.
- Several genetic variants of AJAP1, including the p.(W183C), have been associated with epilepsy and neurodevelopmental disorders, particularly affecting its ability to bind GBRs.
- Mice lacking functional AJAP1 showed decreased levels of presynaptic GBRs, leading to impaired synaptic inhibition and plasticity, highlighting the importance of AJAP1 in regulating neurotransmitter release.
Voltage-gated Ca2.1 (P/Q-type) Ca channels play a crucial role in regulating neurotransmitter release, thus contributing to synaptic plasticity and to processes such as learning and memory. Despite their recognized importance in neural function, there is limited information on their potential involvement in neurodegenerative conditions such as Alzheimer's disease (AD).
View Article and Find Full Text PDFDespite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory symptoms is often predictive of the expression of other autistic traits. However, the origin of these perceptual deficits remains largely elusive.
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