The structure of the Lujo virus spike complex.

Lujo virus (LUJV) is a human pathogen that was the cause of a deadly hemorrhagic fever outbreak in Africa. LUJV is a divergent member of the Arenaviridae with some similarities to both the "Old World" and "New World" serogroups, but it uses a cell-entry receptor, neuropilin-2 (NRP2), that is distinct from the receptors of OW and NW viruses. Though the receptor binding domain of LUJV has been characterized structurally, the overall organization of the trimeric spike complex and how NRP2 is recognized in this context were unknown.

Homozygote Depression in Gamete-Derived Dragon-Fruit () Lines.

Putative gamete-derived progenies from two species, the diploid and the tetraploid , were studied with the dual aims to confirm their gamete origin and to evaluate their potential use as genetic resources. An additional goal was to determine the origin (allotetraploid vs. autotetraploid) of by exploring morphological variations in the di-haploid (2) progeny.

, an Desert Relative, Is Tolerant to Multiple Abiotic Stresses and Exhibits Species-Specific and Common Stress Tolerance Strategies with Its Halophytic Relative, () .

The search for novel stress tolerance determinants has led to increasing interest in plants native to extreme environments - so called "extremophytes." One successful strategy has been comparative studies between and extremophyte relatives such as the halophyte located in areas including cold, salty coastal regions of China. Here, we investigate stress tolerance in the desert species, (True Rose of Jericho), a member of the poorly investigated lineage III .

Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndrome.

Human telomeric regions are packaged as constitutive heterochromatin, characterized by extensive subtelomeric DNA methylation and specific histone modifications. ICF (immunodeficiency, centromeric instability, facial anomalies) type I patients carry mutations in DNA methyltransferase 3B (DNMT3B) that methylates de novo repetitive sequences during early embryonic development. ICF type I patient fibroblasts display hypomethylated subtelomeres, abnormally short telomeres and premature senescence.

Low induction of non-photochemical quenching and high photochemical efficiency in the annual desert plant Anastatica hierochuntica.

Non-photochemical quenching (NPQ) plays a major role in photoprotection. Anastatica hierochuntica is an annual desert plant found in hot deserts. We compared A.