Publications by authors named "R Shafer"
Treatment of obesity is a public health priority. However, little training in obesity medicine is currently integrated into residency programs. We integrated a 12-month obesity medicine training experience within a New York internal medicine residency program.
View Article and Find Full Text PDFIntroduction: Few data are currently available on the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTI) resistance mutations selected in persons living with HIV-1 (PLWH) who develop virological failure while receiving rilpivirine (RPV).
Methods: We analyzed pooled HIV-1 RT genotypic data from 280 PLWH in the multicenter EuResist database and 115 PLWH in the Stanford HIV Drug Resistance Database (HIVDB) who received RPV as their only NNRTI.
Results: Among the 395 PLWH receiving RPV, 180 (45.
Article Synopsis
- * It includes recommendations for using the anti-SARS-CoV-2 neutralizing antibody pemivibart as pre-exposure prophylaxis based on systematic review evidence.
- * The guidelines follow GRADE methodology for assessing evidence certainty and strength of recommendations, and pemivibart is included in the FDA's Emergency Use Authorization.
Importance: Previous studies have identified mutations in SARS-CoV-2 strains that confer resistance to nirmatrelvir, yet how often this resistance arises and its association with posttreatment virologic rebound is not well understood.
Objective: To examine the prevalence of emergent antiviral resistance after nirmatrelvir treatment and its association with virologic rebound.
Design, Setting, And Participants: This cohort study enrolled outpatient adults with acute COVID-19 infection from May 2021 to October 2023.
Article Synopsis
- The study examines how autistic individuals differ from neurotypical controls in terms of sustained fine motor control, focusing on the roles of visual feedback and motor memory.
- Fifty-four autistic participants and 31 neurotypical controls aged 10-25 performed tests involving force sensors to measure their precision grip under visual and memory-guided conditions.
- Results revealed that younger autistic individuals had less force accuracy and more variability during motor tasks compared to controls, but these differences seemed to level out as they reached adolescence.