Publications by authors named "R Sghiri"
Purpose: FRAX is a tool used for evaluation of risk of fracture in RA and non-RA patients and to identify those eligible for intervention. One of the limitations of FRAX in RA settings is that it does not consider factors known to contribute to osteoporosis such as autoantibodies. This study analysed the association of anti-mutated citrullinated vimentin antibody (anti-MCV), anti-cyclic citrullinated peptide antibody (anti-CCP), IgM rheumatoid factor (RF), IgA RF with 10-year risk of major osteoporosis and hip fracture.
View Article and Find Full Text PDFDiagnostic performances of celiac disease serological tests among Saudi patients.
Saudi J Gastroenterol
January 2023
Article Synopsis
- This study investigated the effectiveness of different blood tests for diagnosing celiac disease (CD) among Saudi Arabian children and adults, finding a high prevalence of the condition in the country.
- The research analyzed 148 patients with CD and 512 controls, focusing on tests like IgA anti-tissue transglutaminase antibodies (TTG) and endomysium antibodies (EMA).
- Results showed that IgA anti-TTG was the most sensitive test, and EMA was the most specific, suggesting that using these tests could reduce the need for invasive intestinal biopsies in many patients.
Objectives: Little is known about genes predisposing to systemic bone loss (SBL) in rheumatoid arthritis (RA). Therefore, we examined the association between SBL and variants of genes playing a critical role in both immune response and bone homeostasis among patients with RA.
Methods: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.
Introduction: Autoantibodies such as IgM rheumatoid factor (RF) and anti-citrullinated proteins/peptides antibodies (ACPA) have previously been incriminated in systemic bone loss in rheumatoid arthritis (RA). There are, however, no data describing association of IgA RF and IgG RF with systemic bone loss.
Objective: This study was aimed to investigate the association of RF isotypes with systemic bone loss among patients with RA.
Introduction: Interleukin-1 receptor-associated kinases (IRAKs) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways. They play a key role in inflammation and innate immunity. IRAKs have been previously incriminated in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis and inhibition of IRAKs has been recently regarded as a potential therapeutic strategy for SLE.
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