Matrix metalloproteinases (MMPs), responsible for extracellular matrix remodelling and processing of numerous soluble and cell-surface proteins, appear to play important roles in pathogenesis of gastrointestinal diseases. MMPs influence migration of inflammatory cells, mucosal destruction, matrix deposition and degradation. In this study, we analysed the expression of MMP-19 in the main forms of gastrointestinal diseases including inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease, and colorectal carcinoma.
View Article and Find Full Text PDFObjective: To assess the standard diagnostic and therapeutic algorithm of erectile dysfunction (ED) after radical operations on account of rectosigmoid tumours.
Material And Methods: At the Faculty Hospital in Plzen from Jan. 1995 till Oct.
Under certain extreme conditions in abdominal surgery, such as in septic complications of resections of the GIT with dehiscence of the anastomosis the only possible surgical approach is classical laparostomy. In the latter, contrary to the technique of temporary closure, the abdominal cavity is left open. After control of the sepsis usually the greatest problem is treatment of the defect in the abdominal wall with a fistula of the GIT.
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