CDK6 activity in a recurring convergent kinase network motif.

In humans, more than 500 kinases phosphorylate ~15% of all proteins in an emerging phosphorylation network. Convergent local interaction motifs, in which ≥two kinases phosphorylate the same substrate, underlie feedback loops and signal amplification events but have not been systematically analyzed. Here, we first report a network-wide computational analysis of convergent kinase-substrate relationships (cKSRs).

The use of the Ganga Hospital Score to predict the treatment and outcome of open fractures of the tibia.

Aims: Open fractures of the tibia are a heterogeneous group of injuries that can present a number of challenges to the treating surgeon. Consequently, few surgeons can reliably advise patients and relatives about the expected outcomes. The aim of this study was to determine whether these outcomes are predictable by using the Ganga Hospital Score (GHS).

Evaluation of kinetic friction between regular and colored titanium molybdenum alloy archwires.

Aim: The aim of this study was to evaluate the kinetic frictional properties of colored titanium molybdenum alloy (TMA) archwires (purple-coated TMA and honey dew-coated TMA) and the regular TMA archwires.

Materials And Methods: The experiment comprised of three groups, Group I - Regular TMA archwires, Group II - Purple-coated TMA archwires, Group III - Honey dew-coated TMA wires involving 21 samples each that were evaluated for their frictional properties using Instron Universal Testing Machine.

Results: The results were subjected to statistical analysis using analysis of variance wherein Group I Regular TMA wires revealed mean kinetic frictional value of 8.

Evaluating the Correlation between Anteroposterior and Mediolateral Compensatory Curves and their Influence on Dentoskeletal Morphology-An In vitro CBCT Study.

Introduction: To date, many orthodontist corrects malocclusion based on patients aesthetic concern and fails to correct the compensatory curves. This scenario is due to less insight on understanding relationship of compensatory curves and its correlation in treatment prognosis.

Aim: The purpose of this study was to evaluate the correlation between the curve of Spee, curve of Monson and curve of Wilson, their influence on dentoskeletal morphology and their contribution to occlusal stability.