Pharmaceutical availability of papaverine hydrochloride from spray-dried products prepared with cellulose phthalates.

Papaverine hydrochloride suspensions in acetone/methanol (1:1) solutions of cellulose acetate phthalate, hydroxypropylmethyl cellulose phthalate HP 50 and HP 55 were spray-dried by means of Aeromatic, type Strea-1 device. Encapsulated particles were characterized by drug content, average volume-surface, flow rates, and porosities. Encapsulated products were compressed with and without additives (10% corn starch, 3% talc and 1.

Paracetamol release from spray-dried products prepared with acrylic resins.

Ethanolic solutions of various paracetamol (acetaminophen)/Eudragit E, S, and RS ratios were spray-dried to obtain solid particulates. The products were tableted and the dissolution test of the tablets in distilled water and test solution (pH 1.2 and 7.

Dissolution of metronidazole from oral and vaginal dosage forms in sink and non-sink conditions.

The pharmaceutical availability of metronidazole from several commercial oral and vaginal dosage forms in sink and non-sink conditions has been examined by measuring the rate of drug dissolution. The results were interpreted by means of reversible and irreversible dissolution models. For non-sink conditions the reversible model was found to better interpret the data.

Pharmaceutical availability from oral dosage forms: in vitro release of nitrofurantoin from tablets and capsules.

The pharmaceutical availability of nitrofurantoin in three commercial urinary antiseptic preparations for oral use was assessed by an in vitro determination of drug release into a strongly acidic, a weakly acidic and a weakly basic medium. The following parameters are reported: t87.5%, tdiss, X0 (percentage released immediately on contact with medium), krel (relative dissolution rate constant), and dissolution efficiency (DE).