Publications by authors named "R Senese"
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and impaired beta-cell secretory function. Since existing treatments often present side effects based on different mechanisms, alternative therapeutic options are needed. In this scenario, the present study first evaluates the cytotoxicity of decoctions from the leaves, stems, and roots of L.
View Article and Find Full Text PDFIntroduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.
Methods: We used CB1 and CB1 male mice.
Comparative effects of 3,5-diiodo-L-thyronine and 3,5,3'-triiodo-L-thyronine on mitochondrial damage and cGAS/STING-driven inflammation in liver of hypothyroid rats.
Front Endocrinol (Lausanne)
September 2024
Maintaining a well-functioning mitochondrial network through the mitochondria quality control (MQC) mechanisms, including biogenesis, dynamics and mitophagy, is crucial for overall health. Mitochondrial dysfunction caused by oxidative stress and further exacerbated by impaired quality control can trigger inflammation through the release of the damage-associated molecular patterns (mtDAMPs). mtDAMPs act by stimulating the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how cannabinoid type 1 receptor (CB1) signaling affects the gastrocnemius muscle, particularly its role in maintaining mitochondrial balance and function.
- - Observations indicate that mice lacking CB1 show changes in muscle fiber composition, with more oxidative fibers and improved oxidative capacity, yet this comes with increased oxidative stress and weakened antioxidant defenses.
- - Findings suggest that CB1 influences not only mitochondrial production and dynamics but also protein quality control, revealing complex interactions that enhance our understanding of muscle physiology and cellular adaptability to CB1 signaling.
Article Synopsis
- Small non-coding RNAs (ncRNAs), especially miRNAs, are crucial for many biological processes related to both health and disease, and they can move between different cell compartments.
- This study discovered piRNAs (a type of ncRNA) in mitochondria for the first time, highlighting a significant link between mitochondria and piRNA pathways across various mouse tissues.
- The research also identified both shared and unique mitochondrial miRNAs (mitomiRs) in different tissues, which may be tied to the fundamental or context-specific functions of mitochondria, providing valuable insights for future studies on ncRNA regulation and mitochondrial roles.