Contribution of Ethnomedical Use Data to the Marketing Authorization of Traditional Herbal Medicines in Mali.

Background: To improve the supply of health care and health care products, traditional herbal medicines that are safe, effective, and of good quality need marketing authorizations. This study aims to determine the contribution of ethnomedical evidence to the marketing of traditional herbal medicines in Mali.

Methods: This was a descriptive cross-sectional study conducted from December 2023 to March 2024 supplemented by a literature review of the legislative and regulatory provisions relating to traditional medicine and the requirements for marketing authorization of traditional herbal medicines in Mali and the West African sub-region.

Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs.

High solubility in water and physiological fluids is an indispensable requirement for the pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well established that pharmaceutical substances exhibiting limited solubility in water are inclined towards diminished and inconsistent absorption following oral administration, consequently resulting in variability in therapeutic outcomes. The current advancements in combinatorial chemistry and pharmaceutical design have facilitated the creation of drug candidates characterized by increased lipophilicity, elevated molecular size, and reduced aqueous solubility.

A review of the safety profile, antioxidant, anti-inflammatory, and bronchorelaxant activities of Linn (Malvaceae): A potential antiasthmatic phytomedicine.

Introduction: Linn (Malvaceae) is a widely distributed plant in West Africa. It is commonly used in Burkina Faso to treat inflammation-related diseases, including asthma. Previous reviews have focused on the ethnobotanical, traditional uses, phytochemistry, and pharmacological properties of .

Synthesis, structure and Hirshfeld surface analysis of 2-oxo-2-chromen-4-yl penta-noate.

In the title compound, CHO, the dihedral angle between the coumarin ring system (r.m.s deviation = 0.