Publications by authors named "R Sembiring"
Article Synopsis
- COVID-19 continues to impact global health significantly, with its mechanisms not fully understood; key players in the virus's entry into cells are ACE2 and TMPRSS2, whose genetic variations have been studied for their impact on disease severity.
- A study conducted in 2022 involving 151 hospitalized COVID-19 patients in Indonesia assessed the relationship between specific genetic polymorphisms (rs2074192 and rs12329760) and the outcomes of the disease, along with demographic data and health status.
- Although the study found no strong links between the tested genetic variants and severe disease outcomes, it did note that the TMPRSS2 SNP was associated with higher mortality, and that ACE2 protein levels differed significantly between
Background/aims: Traumatic brain injury is a significant public problem with an incidence of 10 million people per year, causing the largest deaths and disabilities worldwide. Head injuries can be classified into primary and secondary head injuries. Secondary head injuries can be caused by several factors such as ischemia, cerebral edema, and neuroinflammation.
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- Pregnant women with latent tuberculosis infection (LTBI) are at increased risk for calcitriol deficiency, which impacts their newborns' immune responses.
- In a study with 84 women, those with LTBI showed higher levels of cathelicidin and interferon gamma (IFN-γ) compared to those without LTBI.
- The research highlights the importance of monitoring calcitriol and immune markers in both LTBI pregnant women and their newborns to potentially develop preventative TB strategies.
Coronary artery disease (CAD) remains a significant global health concern with considerable high morbidity and mortality and its development is influenced by various genetic and environmental factors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a vital regulator of low-density lipoprotein receptor (LDLR) metabolism, directly impacting serum cholesterol levels. However, its role in development of CAD is not fully understood.
View Article and Find Full Text PDFDegree of kidney injury due to artificial pelvic-ureteric junction obstruction with level of neutrophil gelatinase-associated lipocalin, interleukin 18, and histopathological descriptions in Wistar: experimental research.
Ann Med Surg (Lond)
June 2023
Article Synopsis
- Pelvic-ureteric junction obstruction (PUJO) is a leading cause of hydronephrosis in newborns, and early detection is crucial for preventing kidney damage and complications, especially when surgical intervention like pyeloplasty is required.
- This study examined the relationship between urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin 18 (IL-18) levels, as well as the degree of kidney damage in Wistar rats with PUJO over different time points.
- The findings suggest that while NGAL levels did not show significant changes, IL-18 levels varied significantly across different groups and time points, indicating it could be a useful biomarker for predicting kidney damage in PUJO cases