Publications by authors named "R Scott Powers"
The medial prefrontal cortex (mPFC) plays a critical role in emotional regulation, and its dysregulation is linked to anxiety disorders. In particular, the prelimbic cortex (PrL) of the mPFC is thought to modulate anxiety-related behaviors, though its precise role remains debated. Here, we used endoscopic in vivo calcium imaging to assess PrL neuronal activity in male and female Sprague-Dawley rats performing in the Elevated Plus Maze (EPM), a widely used task to measure anxiety-like behavior.
View Article and Find Full Text PDFUnlabelled: Endothelial-to-mesenchymal transition (EndMT) is a biological process that converts endothelial cells to mesenchymal cells with increased proliferative and migrative abilities. EndMT has been implicated in the development of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), a fatal and progressive lung vascular disease. Transforming growth factor β (TGF-β ), an inflammatory cytokine, is known to induce EndMT in many types of endothelial cells including lung vascular endothelial cells (LVEC).
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- Luteinizing hormone (LH) is key for ovulation and progesterone production across species but knowledge gaps remain about the metabolic processes involved.
- Research using metabolomics in luteal cells shows that LH rapidly activates pathways that increase glycolysis and oxygen use, stimulating lipid production.
- Discoveries highlight the importance of fatty acid synthesis and oxidation in progesterone production, suggesting potential approaches to improve ovarian function and create non-hormonal contraceptives.
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- Children with autism and other neurodevelopmental concerns often struggle with sensory processing issues and self-regulation difficulties like emotion dysregulation and anxiety, which affects their development.
- This study involved 117 children aged 8-12, aiming to understand the prevalence of self-regulation problems and identify different sensory processing subtypes.
- Findings revealed significant rates of emotion dysregulation (39%), anxiety (19%), and ADHD symptoms (62%), along with five sensory processing subtypes that correlate with various self-regulation challenges, particularly noting distinct patterns among Sensory Over-Responsive and Sensory Seeking groups.
Background: Only a subset of individuals who encounter illicit drugs become persons with a substance use disorder. Individual differences in aversive reactions to drug-associated phenomena like smoke inhalation and unpleasant taste are predictors for continued use. While several preclinical studies have explored self-administration involving aversive cues, none have simultaneously introduced aversion with the initial drug self-administration.
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