Understanding melanoma in situ: Lentigo maligna surgical treatment terminology and guideline adherence, a targeted review.

Background: Malignant melanoma in-situ, lentigo maligna (MMIS-LM) can be successfully treated with several different surgical techniques; however, the literature is inconsistent in defining them.

Objective: To comprehensively define and describe the national guideline recommended surgical techniques used to treat MMIS-LM to help clarify and standardize this terminology to ensure compliance with the guidelines.

Methods: A targeted literature review was performed from 1990 to 2022 focusing on articles that discussed the national guideline recommended surgical techniques of wide local excision, Mohs micrographic surgery (MMS), modified Mohs surgery, and staged excision/Slow-Mohs for MMIS-LM, as well as the related methods of tissue processing.

Postoperative MRI Surveillance of Vestibular Schwannomas: Is There a Standard of Care?

Objective: To examine current practices for postoperative imaging surveillance following vestibular schwannoma resection.

Study Design: Cross-sectional survey of practicing neurotologists.

Setting: Tertiary referral centers.

Identification and characterization of novel perivascular adventitial cells in the whole mount mesenteric branch artery using immunofluorescent staining and scanning confocal microscopy imaging.

A novel perivascular adventitial cell termed, adventitial neuronal somata (ANNIES) expressing the neural cell adhesion molecule (NCAM) and the vasodilator neuropeptide, calcitonin gene-related peptide (CGRP), exists in the adult rat mesenteric branch artery (MBA) in situ. In addition, we have previously shown that ANNIES coexpress CGRP and NCAM. We now show that ANNIES express the neurite growth marker, growth associated protein-43(Gap-43), palladin, and the calcium sensing receptor (CaSR), that senses changes in extracellular Ca(2+) and participates in vasodilator mechanisms.

Psychosocial factors contribute to resting blood pressure in African Americans.

Objectives: African Americans as a group have higher blood pressure than individuals of northern European ancestry (non-Hispanic Whites). We investigate whether psychosocial factors explain the resting blood pressure of healthy, community-dwelling African Americans in our study.

Participants: A convenience sample of self-reported normotensive African Americans aged 18-65 years who live in the North Carolina Triangle region.

Action of thiazide on renal interstitial calcium.

Background: Although thiazides increase urinary sodium excretion, they also decrease urinary calcium excretion. Recent studies in our laboratory have shown that increased dietary salt significantly reduces interstitial fluid calcium in Dahl salt-sensitive (DS) rats, and this was associated with a rise in blood pressure and increased urinary calcium excretion. Owing to the vasorelaxant actions of increased extracellular fluid calcium, we reasoned that the antihypertensive action of hydrochlorothiazide (HCTZ), a commonly used thiazide, may be the result of increased interstitial fluid calcium as a consequence of decreased urinary calcium excretion.