Publications by authors named "R Schoborg"

Article Synopsis
  • Azelastine hydrochloride, an H1 receptor antagonist, shows anti-chlamydial effects in both genital and ocular infection models using HeLa and conjunctival epithelial cells.
  • The timing of azelastine application is crucial, demonstrating more significant results when applied before or shortly after chlamydial infection, leading to reduced inclusion size and infectivity.
  • The study suggests that the anti-chlamydial effects of azelastine likely operate through mechanisms independent of H1 receptor modulation and may involve off-target actions.
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Chlamydia trachomatis and Neisseria gonorrhoeae are the most frequently reported agents of bacterial sexually transmitted disease worldwide. Nonetheless, C. trachomatis/N.

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(CT) (NG) cause most bacterial sexually transmitted infections (STIs) worldwide. Epidemiological studies have shown high percentages of co-infections with CT/NG and indicate that NG co-infection can reactivate CT shedding during persistent chlamydial infection. These data also suggest that biological interaction between the two bacteria may increase susceptibility or transmissibility.

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Water-filtered infrared A (wIRA) alone or in combination with visible light (VIS) exerts anti-chlamydial effects in vitro and in vivo in acute infection models. However, it has remained unclear whether reduced irradiation duration and irradiance would still maintain anti-chlamydial efficacy. Furthermore, efficacy of this non-chemical treatment option against persistent (chronic) chlamydial infections has not been investigated to date.

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(Ct) and (Ng) are the most common bacterial sexually transmitted infections (STIs) worldwide. The primary site of infection for both bacteria is the epithelium of the endocervix in women and the urethra in men; both can also infect the rectum, pharynx and conjunctiva. Ct/Ng co-infections are more common than expected by chance, suggesting Ct/Ng interactions increase susceptibility and/or transmissibility.

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