In Vivo Nanodiamond Quantum Sensing of Free Radicals in Caenorhabditis elegans Models.

Free radicals are believed to play a secondary role in the cell death cascade associated with various diseases. In Huntington's disease (HD), the aggregation of polyglutamine (PolyQ) not only contributes to the disease but also elevates free radical levels. However, measuring free radicals is difficult due to their short lifespan and limited diffusion range.

Diamond Surfaces with Lateral Gradients for Systematic Optimization of Surface Chemistry for Relaxometry - a Low-Pressure Plasma-Based Approach.

Diamond is increasingly popular because of its unique material properties. Diamond defects called nitrogen vacancy (NV) centers allow for measurements with unprecedented sensitivity. However, to achieve ideal sensing performance, NV centers need to be within nanometers from the surface and are thus strongly dependent on the local surface chemistry.

In silico vaccine design: Targeting highly epitopic regions of type D epsilon toxin and type B alpha toxin for optimal immunogenicity.

Livestock infections caused by highly toxic bacteria, such as type D and type B, present significant challenges in veterinary medicine. Such infections often require complex and elusive treatment regimens. Developing effective vaccines tailored to combat these specific pathogens remains a pressing need within the field.

Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents.

Skin equivalents (SE) that recapitulate biological and mechanical characteristics of the native tissue are promising platforms for assessing cosmetics and studying fundamental biological processes. Methods to achieve SEs with well-organized structure, and ideal biological and mechanical properties are limited. Here, the combination of melt electrowritten PCL scaffolds and cell-laden Matrigel to fabricate SE is described.