Publications by authors named "R Scaramuzzo"
The high-altitude hypoxia model demonstrates that insufficiently oxygenated placentas activate compensatory mechanisms to ensure fetal survival, hinging on the transcription factor hypoxia-inducible factor-1. The aim of the present study is to investigate whether and when similar mechanisms are also activated during intrauterine growth restriction (IUGR). A retrospective observational study evaluated a series of umbilical cord blood samples, which provide a realistic representation of the fetal intrauterine status, collected from a cohort of preterm and term neonates, both affected and not affected by IUGR.
View Article and Find Full Text PDFAt different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia-inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low-oxygen environment, including the induction of specific enzymes related to glycolytic metabolism, erythropoiesis, angiogenesis, and vasculogenesis. However, oxygen concentrations fluctuate during intrauterine life, enabling the induction of tissue-specific differentiation processes.
View Article and Find Full Text PDFArticle Synopsis
- - The COVID-19 pandemic led to the adoption of innovative teaching methods, with digital game-based learning (DGBL) emerging as an effective alternative for remote training, particularly in medical fields.
- - A study assessed the effectiveness of DGBL using a game focused on neonatal resuscitation with 52 anesthesiologist trainees, comparing their progress to that of a control group who underwent traditional in-person training.
- - Results showed that the DGBL method improved knowledge and skills in specific areas without significant benefits from supervised DGBL, suggesting that future versions should include multiplayer options to enhance collaboration and teamwork among users.
Article Synopsis
- The development of embryos and fetuses occurs in a low-oxygen environment regulated by factors like HIF-1 and β3-adrenergic receptors (β3-ARs), and issues related to prematurity may arise from reduced β3-AR function due to premature oxygen exposure.
- This research aims to study the relationship between oxygen levels and the expression of HIF-1, β3-ARs, and VEGF in preterm and full-term newborns by collecting and analyzing cord blood samples.
- The study has received ethical approval and involves enrolling 100 preterm and 100 full-term newborns to identify correlations between gene expression and clinical outcomes, potentially offering new insights for
Article Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.