Publications by authors named "R Scalia"
Article Synopsis
- Supine percutaneous nephrolithotomy (PCNL) has emerged as a safe and effective alternative to the traditionally used prone position for treating urinary stones in patients with horseshoe kidneys (HSK).
- A study analyzed data from 35 HSK patients who underwent 48 PCNL procedures from June 2016 to June 2023, reporting a stone-free rate of 72.9% after one month.
- Complications were relatively low, with 22.9% of procedures resulting in minor complications (Grade I-II) and only one case of a more severe complication (Grade IIIa).
Background And Objective: Recently, the new pulsed thulium:yttrium aluminum garnet (p-Tm:YAG) laser technology has been introduced in endourology for lithotripsy. The aim of this study was to assess and validate the clinical laser performance and safety profile of p-Tm:YAG laser in a series of patients with renal and ureteral stones who underwent flexible ureteroscopy (fURS).
Methods: Prospective data were collected for patients who underwent fURS with the p-Tm:YAG laser Thulio (Dornier MedTech Systems GmbH, Wessling, Germany) at our institution by using two different laser fiber core diameters (270 and 200 μm).
Background: Interstitial lung disease (ILD) encompasses a heterogeneous group of disorders sharing pathophysiological inflammatory mechanisms, leading to parenchymal distortions. The prevalence of ILD with new cancer drugs is underreported: the identification of potential determinants is priority.
Materials And Methods: ILDE is a retrospective study aimed at describing the clinical course and potential determinants of ILD in patients receiving experimental treatments.
Background: Platinum-based chemotherapy represents the standard first-line treatment for biliary tract cancers (BTC). Deficits in genes involved in the homologous recombination (HR) and DNA damage response (DDR) may confer higher sensitivity to platinum agents.
Methods: We retrospectively included patients affected by BTC from 2 Italian institutions.
Article Synopsis
- Mitochondrial dysfunction plays a role in cardiovascular diseases, especially hypertension, with a focus on the balance of mitochondrial fission and fusion.
- In a study using C57BL6 mice, the mitochondrial fission inhibitor mdivi1 was shown to reduce hypertension and related vascular changes induced by angiotensin II.
- Mdivi1 not only limited vessel fibrosis and hypertrophy but also improved mitochondrial structure and reduced cardiac hypertrophy and vascular reactivity associated with angiotensin II treatment, indicating multiple protective mechanisms in the vasculature.