Effects of sofalcone on necrotizing agents-induced gastric lesions and on endogenous prostaglandins in rats stomachs.

Attempts were made to investigate the effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on necrotizing agents-induced gastric lesions and on prostaglandin E2 (PGE2)-like activity of the gastric tissue in rats. Sofalcone, 100 mg/kg i.p.

Effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on chronic gastric ulcers in rats.

The anti-ulcer effect of sofalcone, an isoprenyl chalcone derivative, on acetic acid-induced gastric ulcers in rats was studied histologically and histochemically. After administrations of sofalcone at 50 and 200 mg/kg twice daily for 10 days, contraction of the ulcer, mucosal regeneration, accelerated development of the collagen fibers in the granulation tissue at the base of the ulcer, and increase of acid mucopolysaccharides, an alcian blue stain-positive substance covering the regenerated mucosa, were noted. The healing effect of sofalcone was balanced in mucosal regeneration and connective tissue proliferation (formation of the collagen fibers).

Effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy)chalcone (SU-88) on gastric local blood flow.

Effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy)chalcone (SU-88), a new anti-ulcer drug, on gastric tissue blood flow was investigated by using an inhaled hydrogen gas clearance method in rats. As a result, following the intravenous infusions of 10,20 and 30 mg/kg/h of SU-88, the gastric blood flow increased with an increase rate of 38.1, 70.

[Effects of the anti-ulcer drug SU-88 on the gastric blood flow and the cardiovascular system (author's transl)].

Effects of a newly synthetized anti-ulcer drug, 2'Carboxymethoxy-4,4'-bis(3-methyl-2-butenloxy)chalcone (SU-88), on gastric blood flow and the cardiovascular system were investigated. Intravenously administered SU-88 dose-dependently increased the blood flow of gastric tissues in rats. In anethetized dogs, i.