Publications by authors named "R Sarkany"
Background: Poor adherence to photoprotection in Xeroderma Pigmentosum (XP) increases morbidity and shortens lifespan due to skin cancers.
Objective: To test a highly personalised intervention (XPAND) to reduce the dose of ultraviolet radiation (UVR) reaching the face in adults with XP, designed using known psychosocial determinants of poor photoprotection.
Methods: A two-arm parallel group randomised controlled trial, including patients with sub-optimal photoprotection to receive XPAND or a delayed intervention control arm that received XPAND the following year.
Article Synopsis
- Voriconazole (VOR), an anti-fungal drug, can cause phototoxicity and skin cancer by impairing the DNA repair process known as nucleotide excision repair (NER).
- VOR affects NER not by changing the expression of related genes but by binding to heterochromatin, disrupting the acetylation of histone H3, which is necessary for effective DNA repair.
- Using histone deacetylase inhibitors to restore H3 acetylation can reverse the NER inhibition caused by VOR, suggesting a potential therapeutic strategy to prevent its harmful effects.
Article Synopsis
- The study highlights the effectiveness of traditional therapeutic plasmapheresis (TPE) as a treatment for difficult cases of solar urticaria (SU) that don't respond to common medications.* -
- A specific case involving a patient who underwent 42 TPE procedures over five years showed significant improvement in their condition, as indicated by increased resistance to UV light during testing after treatment.* -
- The research also compares the outcomes of this case with previous studies on TPE for SU, showing that patients with positive intradermal tests generally benefited more from TPE, although some relapsed in a short time.*
Article Synopsis
- Porphyria cutanea tarda (PCT) is the most common type of porphyria and often linked to underlying health issues, significantly affecting liver health and longevity.* -
- Correct diagnosis and treatment of PCT are essential for clinicians, as it is a manageable disease with treatable complications.* -
- Recent advancements in understanding PCT and its health impacts can enhance clinical management, making it crucial for healthcare providers to stay updated.*