Publications by authors named "R Sarabia-Estrada"
Study Design: Human bone marrow stem cells (hBMSCs) and human adipose-derived stem cells (hADSCs) have demonstrated the capability to regenerate bone once they have differentiated into osteoblasts.
Objective: This systematic review aimed to evaluate the in vitro osteogenic differentiation potential of these cells when seeded in a poly (lactic--glycolic) acid (PLGA) scaffold.
Methods: A literature search of 4 databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted in January 2021 for studies evaluating the osteogenic differentiation potential of hBMSCs and hADSCs seeded in a PLGA scaffold.
Objective: The vertebral column is the most common site for skeletal metastasis, often leading to debilitating pain and weakness. Metastatic cancer has unique genetic drivers that potentiate tumorigenicity. There is an unmet need for novel targeted therapy in patients with spinal metastatic disease.
View Article and Find Full Text PDFMetabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM tumor initiating cells. GBM tumor initiating cells were treated at different times with melatonin (1.
View Article and Find Full Text PDFArticle Synopsis
- ADSCs (adipose-derived mesenchymal stem cells) may prevent distal skin flap necrosis effectively in preclinical studies, but human ADSCs (hADSCs) need to be tested for clinical applicability.
- A review of studies showed that hADSCs reduce necrotic skin area by 18.04%, while animal ADSCs reduce it by 22.37%, with no significant difference in effectiveness between the two.
- The findings support the use of hADSCs in animal models to facilitate their transition into clinical trials, potentially improving surgical outcomes for patients.