Making sense of the costs of adversity throughout the lifespan on aging in humans and other animals.

Social adversity, particularly early in life, can cause lifelong damage to health; by now, numerous studies examine this relationship in non-human species, producing some important themes: A) Captive animals readily lack ethological validity, giving a special place to studies of natural populations; one must appreciate though, that animal studies typically benefit humans who themselves lack ecological validity, namely Westernized subjects. B) Animal studies of the links between social adversity and psychiatric maladies potentially produce anthropomorphism; however, long-term study of our closest relatives demonstrates how convincingly another primate can, for example, experience grief, rather than display "grief-like" behavior. C) Are long-term consequences of social adversity best viewed as maladaptive and pathological, or as adaptive preparation for similar adversity later in life?; the growing literature casts light on when adversity's consequences are the purview of medicine or natural history.

2022 ISPNE Bruce McEwen Lifetime Achievement award: Stress, from molecules to societies.

The International Society for Psychoneuroendocrinology meeting in Chicago in 2022 was thrilled to recognize Dr. Robert Sapolsky with the Bruce McEwen Lifetime Achievement award. This is the second year for the award to be named to honor Bruce McEwen and it marks the completion of a special issue edited by Blazej Miziak and Robert Paul Juster in the journal Psychoneuroendocrinology dedicated to Bruce's legacy and the unfathomable contribution of Allostatic Load to the stress field.

Glucocorticoids, the evolution of the stress-response, and the primate predicament.

The adrenocortical stress-response is extraordinarily conserved across mammals, birds, fish, reptiles, and amphibians, suggesting that it has been present during the hundreds of millions of years of vertebrate existence. Given that antiquity, it is relatively recent that primate social complexity has evolved to the point that, uniquely, life can be dominated by chronic psychosocial stress. This paper first reviews adrenocortical evolution during vertebrate history.