Publications by authors named "R Sanz"
Article Synopsis
- A study aimed at understanding colorectal cancer (CRC) biology identified early diagnostic markers through quantitative proteomics of tissue samples from patients with stage I sporadic CRC.
- Two experiments using advanced mass spectrometry techniques revealed 2,681 proteins, with 284 upregulated and 280 downregulated in adenoma and adenocarcinoma tissues compared to healthy samples.
- Further investigation of ten dysregulated proteins showed that SLC8A1 and TXNDC17 are crucial for CRC development and could serve as potential early diagnostic markers in plasma tests.
Acute kidney injury (AKI) is a frequent complication in patients undergo-ing cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) due to a combination of several factors: increased intra-abdominal pressure, heat stress and drug tox-icity. Patients admitted to Intensive Care Unit after CRS and HIPEC during 129 months. Data recorded were: demographic characteristics; severity of illness, haematology and basic chemistry panels (renal function and electrolytes), type of cancer and extension, HIPEC drug and temperature, fluid balance, ICU and hospital stay and mortality.
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- The study investigates protein-rich inclusions in neurodegeneration, noting that current iPSC models lack reproducibility and speed in developing these inclusions.
- Researchers created new iPSC models that allow for rapid production of CNS cells with proteins prone to aggregation, enabling the tracking of inclusions at a single level.
- They identified various inclusion types with differing effects on neuron survival and isolated proteins that could influence toxicity, paving the way for improved drug development for neurodegenerative diseases.
A selective, metal-free synthesis of boron-functionalized indenes and benzofulvenes via BCl-mediated cyclization of -alkynylstyrenes is described. The method allows precise control over product formation by adjusting reaction conditions. These borylated products were utilized in diverse C-B bond derivatizations and in the total synthesis of Sulindac, a nonsteroidal anti-inflammatory drug, demonstrating the versatility and practicality of the developed methodology for synthetic applications.
View Article and Find Full Text PDFAutonomous robots are already present in a variety of domains performing complex tasks. Their deployment in open-ended environments offers endless possibilities. However, there are still risks due to unresolved issues in dependability and trust.
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