Effects of subinhibitory concentrations of pefloxacin on the adherence of Staphylococcus aureus to human cells.

The adherence of bacterial strains to eukaryotic cells can be influenced by subinhibitory concentrations of antibiotics. The effect of sub- and infra-MICs of pefloxacin, a new broad-spectrum antibacterial quinolone, on the adherence of Staphylococcus aureus to human buccal cells, was studied. Six S.

[Comparative study of platelet anti-aggregation effect of several anti-inflammatory agents].

The relationships between inflammation and platelets, particularly between inflammation and platelet aggregation, have been elucidated during the last two years. Platelet aggregation is greatly enhanced by PGE2 and PGF2 alpha prostaglandins, which act as mediators of inflammation through the part they play in the regulation of platelet cyclic AMP whose intracellular concentration is determined by PGE1. Recently, acetylsalicylic acid and indomethacin have been shown to inhibit the synthesis and release of PGE2 as well as platelet aggregation.

Plasma binding of an alpha-blocking agent, nicergoline--affinity for serum albumin and native and modified alpha 1-acid glycoprotein.

The binding of nicergoline, an alpha-blocking drug, by human plasma proteins was studied using gel filtration, polyacrylamide gel electrophoresis, and equilibrium dialysis techniques. 3H-labeled nicergoline added to plasma was eluted together with two major protein fractions, one containing mainly serum albumin, the other glycoproteins such as alpha 1-acid glycoprotein (alpha 1-AG). Equilibrium dialysis experiments with pure human serum albumin and alpha 1-AG as well as with its chemically modified forms, desialylated, carboxymethylated, and both desialylated and carboxymethylated alpha 1-AG gave the following results: nicergoline has about a 4-fold higher affinity for alpha 1-AG than for serum albumin.