Publications by authors named "R Santhi"
Purpose: This study aims to comprehensively characterize the clinical, demographic, and histopathological features of ocular adnexal lymphoma (OAL) and assess their impact on patients' survival outcomes.
Methods: A total of 123 patients were included in the study; of these, 93 patients were selected for survival analysis. Survival data were analyzed using the Kaplan-Meier test, and correlation was assessed through the log-rank test and Cox regression analysis.
Background: Ocular adnexal B cell lymphoma is the most common orbital malignancy in adults. Large chromosomal translocations and alterations in cell-signaling pathways were frequently reported in lymphomas. Among the altered pathways, perturbations of NFκB signaling play a significant role in lymphomagenesis.
View Article and Find Full Text PDFRetinoblastoma (RB) is a childhood retinal neoplasm and commonly treated with cytotoxic chemotherapeutic agents. However, these therapeutic approaches often lead to diverse adverse effects. A precise molecular therapy will alleviate these side effects and offer better treatment outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Retinoblastoma (RB) is a rare type of childhood eye cancer that arises from mutations in the RB1 gene and is influenced by changes in gene expression.
- The study utilized a specialized PCR array to analyze 84 cancer-related genes, identifying 68 that were dysregulated in RB tumors, leading to the discovery of key pathways involved in the cancer's development.
- This research highlights potential therapeutic targets and promotes the use of PCR arrays for efficient gene expression assessment in retinoblastoma.