Publications by authors named "R Sanjuan Pinol"
Article Synopsis
- Endotherms, or warm-blooded animals, need to maintain their body temperature by warming up in cold environments and cooling down in hot ones.
- Researchers have discovered a neural pathway that can reverse this typical process, allowing the body to cool down in cold temperatures and heat up in warm conditions.
- This unusual regulatory mechanism is referred to as thermoregulatory inversion, highlighting new insights into how these animals adapt to different thermal challenges.
Across mammalian species, new mothers undergo considerable behavioral changes to nurture their offspring and meet the caloric demands of milk production. While many neural circuits underlying feeding and parenting behaviors are well characterized, it is unclear how these different circuits interact and adapt during lactation. Here, we characterized the transcriptomic changes in the arcuate nucleus (ARC) and the medial preoptic area (MPOA) of the mouse hypothalamus in response to lactation and hunger.
View Article and Find Full Text PDFFrom chemistry design to clinical application, several approaches have been developed to overcome platinum drawbacks in antitumoral therapies. An in-depth understanding of intracellular signaling may hold the key to the relationship of both conventional drugs and nanoparticles. Within these strategies, first, nanotechnology has become an essential tool in oncotherapy, improving biopharmaceutical properties and providing new immunomodulatory profiles to conventional drugs mediated by activation of endoplasmic reticulum (ER) stress.
View Article and Find Full Text PDFPurpose: Aspirin (acetylsalicylic acid) has been reported to protect against certain cancers. However, patient-related risk factors may moderate protective effects, including excess weight, smoking, risky alcohol use, and diabetes. We explore the cancer-risk relationship between aspirin intake and those four factors.
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