Publications by authors named "R Sani"
Background: There is a paucity of nationally representative data on the pattern of morbidity of hospitalised medical patients in Nigeria. We hereby provide insights from the MOHOPA (Pattern of Morbidities, Mortality and Healthcare Financing of Hospitalised Medical Patients in Hospitals) study on the pattern of morbidity among patients admitted to the medical wards of Nigerian tertiary-level hospitals.
Methods: At least 100 patients admitted to the medical and emergency wards of 7 tertiary-level hospitals, spread across the 6 geopolitical zones of Nigeria and the Capital City of Abuja, were consecutively recruited to join the study after obtaining written informed consent.
Exopolysaccharides (EPSs), a constitutive part of bacterial biofilm, act as a protecting sheath to the extremophilic bacteria and are of high industrial value. In this study, we elucidate a new EPS produced by thermotolerant (growth from 34-44 °C) strain Pseudomonas alcaligenes Med1 from Medano hot spring (39.1 °C surface temperature, pH 7.
View Article and Find Full Text PDFBacterial adhesion and biofilm maturation is significantly influenced by surface properties, encompassing both bare surfaces and single or multi-layered coatings. Hence, there is an utmost interest in exploring the intricacies of gene regulation in sulfate-reducing bacteria (SRB) on copper and graphene-coated copper surfaces. In this study, G20 was used as the model SRB to elucidate the pathways that govern pivotal roles during biofilm formation on the graphene layers.
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- Copper ions have toxic effects on bacteria, and this study specifically looked at how different concentrations of copper affect the G20 strain's ability to form biofilms while growing in a lactate-C medium.
- High copper concentrations (5, 15, and 30 µM) reduced the growth of G20 in liquid (planktonic state) but increased biofilm formation on surfaces like glass.
- Microscopic analysis showed that copper-stressed biofilms had changes in cell structure and higher levels of carbohydrates and proteins, along with significant changes in gene expression related to stress response and biofilm formation.
In an environment, microbes often work in communities to achieve most of their essential functions, including the production of essential nutrients. Microbial biofilms are communities of microbes that attach to a nonliving or living surface by embedding themselves into a self-secreted matrix of extracellular polymeric substances. These communities work together to enhance their colonization of surfaces, produce essential nutrients, and achieve their essential functions for growth and survival.
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