Publications by authors named "R Sandoval"
Article Synopsis
- Pharmacological inhibition of megalin in mice helps reduce atherosclerosis, but the study aimed to see if specifically deleting megalin in renal proximal tubule cells (PTCs) could have similar effects against hypercholesterolemia-induced atherosclerosis.
- The experiments involved creating mice with and without megalin (PTC-LRP2 -/-) and inducing atherosclerosis by using a Western diet, but results showed that deleting megalin did not reduce atherosclerosis in any mice.
- Instead, male PTC-LRP2 -/- mice exhibited severe kidney issues, including CD68+ cell infiltration and tubular atrophy, indicating that high-fat diets can lead to kidney damage independent of cholesterol levels, while female P
Unicompartmental knee arthroplasty (UKA) offers a more conservative treatment than total knee arthroplasty when osteoarthritis affects only one tibiofemoral knee compartment. Cemented UKA has become the gold standard due to its good functional outcomes and low revision rates. The most common reasons for revision with cemented UKA include aseptic loss, unexplained pain, and radiolucent lines.
View Article and Find Full Text PDFTo benchmark the accuracy of the models and improve the predictive capability of future experiments, the National Ignition Facility requires measurements of the physical conditions inside inertial confinement fusion hohlraums. The ion temperature and bulk motion velocity of the gas-filled regions of the hohlraum can be obtained by replacing the helium tamping gas in the hohlraum with deuterium-tritium (DT) gas and measuring the Doppler broadening and Doppler shift of the neutron spectrum produced by nuclear reactions in the hohlraum. To understand the spatial distribution of the neutron production inside the hohlraum, we have developed a new penumbral neutron imager with a 12 mm diameter field of view using a simple tungsten alloy spindle.
View Article and Find Full Text PDFBackground: Breast cancer (BC) is the most common cancer among females with Li-Fraumeni syndrome (LFS), but available data on LFS-related BC characteristics are derived from small retrospective cohorts. Prior work has demonstrated a high proportion of HER2-positive BCs, but our understanding of how HER2-positive LFS BCs respond to anti-HER2 treatments is limited.
Methods: BCs diagnosed in patients with germline TP53 variants between 2002-2022 were assembled from three institutions.
Hypothesis: In this communication, we test the hypothesis that sulfotransferase 1C2 (SULT1C2, UniProt accession no. Q9WUW8) can modulate mitochondrial respiration by increasing state-III respiration.
Methods And Results: Using freshly isolated mitochondria, the addition of SULT1C2 and 3-phosphoadenosine 5 phosphosulfate (PAPS) results in an increased maximal respiratory capacity in response to the addition of succinate, ADP, and rotenone.