Publications by authors named "R Sanchez-Prieto"
Ion homeostasis is critical for numerous cellular processes, and disturbances in ionic balance underlie diverse pathological conditions, including cancer progression. Targeting ion homeostasis is even considered as a strategy to treat cancer. However, very little is known about how ion homeostasis may influence anticancer drug response.
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- * In experiments, dinaciclib increased the sensitivity of certain cancer cell lines to radiation but did not significantly affect apoptosis levels or alter certain cellular signaling pathways, suggesting a complex interaction between the drug and radiation.
- * The study highlights how dinaciclib's inhibition of CDK12 leads to reduced BRCA1 levels, which affects DNA repair mechanisms and may contribute to cancer cell aging, proposing a potential personalized treatment approach based on the genetic characteristics of different tumors.
Purpose: To evaluate the impact of sustained hypogonadism after androgen deprivation therapy (ADT) associated with radiotherapy in prostate cancer (PCa) patients with biochemical relapse-free survival (bRFS).
Methods: A retrospective cohort analysis of 213 consecutive PCa patients referred for radiotherapy plus ADT was carried out. Follow-up times including time to testosterone recovery (TTR) and bRFS were calculated from the end of ADT.
Article Synopsis
- Aromatase inhibitors (AIs) like Letrozole are gaining attention for treating hormone-dependent cancers, but they can cause side effects like hot flashes and fibromyalgia while posing risks such as endometrial cancer.
- New AI derivatives inspired by Letrozole have been developed, particularly one with a benzimidazole ring (compound 6), which shows better aromatase inhibitory activity and reduces cancer cell growth compared to established AIs.
- Compound 6 enhances binding to the aromatase enzyme due to its ferrocene structure, leading to improved interaction and increased effectiveness in inhibiting cancer cell proliferation.