Finite element analysis of patient-specific additive-manufactured implants.

Bone tumors, characterized by diverse locations and shapes, often necessitate surgical excision followed by custom implant placement to facilitate targeted bone reconstruction. Leveraging additive manufacturing, patient-specific implants can be precisely tailored with complex geometries and desired stiffness, enhancing their suitability for bone ingrowth. In this work, a finite element model is employed to assess patient-specific lattice implants in femur bones.

Reducing the prosthesis modulus by inclusion of an open space lattice improves osteogenic response in a sheep model of extraarticular defect.

Stress shielding is a common complication following endoprosthetic reconstruction surgery. The resulting periprosthetic osteopenia often manifests as catastrophic fractures and can significantly limit future treatment options. It has been long known that bone plates with lower elastic moduli are key to reducing the risk of stress shielding in orthopedics.

A customized 3D-printed histological microgrinder for the study of metallic endoprostheses.

Use of histology is the key when evaluation of bone and soft tissue integration of any implanted metallic prosthesis is required. This relies on the ability to prepare very thin sections by grinding down resin embedded samples. Manual grinding has historically been used with variable success, and thus, a number of commercial microgrinders have been previously marketed, however, at a significant cost.

Effect of a protease-activated receptor-2 antagonist (GB88) on inflammation-related loss of alveolar bone in periodontal disease.

Background And Objective: Protease-activated receptor-2 (PAR ), a pro-inflammatory G-protein coupled receptor, has been associated with pathogenesis of periodontitis and the resulting bone loss caused by oral pathogens, including the keystone pathogen Porphyromonas gingivalis (P. gingivalis). We hypothesised that administration of a PAR antagonist, GB88, might prevent inflammation and subsequent alveolar bone resorption in a mouse model of periodontal disease.