Predicting the tumor microenvironment composition and immunotherapy response in non-small cell lung cancer from digital histopathology images.

Immune checkpoint inhibitors (ICI) have become integral to treatment of non-small cell lung cancer (NSCLC). However, reliable biomarkers predictive of immunotherapy efficacy are limited. Here, we introduce HistoTME, a novel weakly supervised deep learning approach to infer the tumor microenvironment (TME) composition directly from histopathology images of NSCLC patients.

Stable neodymium gallium oxide (NdGaO and NdGaO) phases: a study on their asymmetric supercapacitor applications.

Rare-earth-based nanomaterials with exceptional electrochemical properties can be obtained a simple, low-cost, environment-friendly citrate-gel-matrix approach. Owing to their high specific capacitance, strong conductivity, and electrochemical stability, gallium-based materials are capable of withstanding numerous charge-discharge cycles, thus extending the life cycle of a supercapacitor. This tunability enabled researchers to alter the morphology and composition of the electrode to enhance supercapacitor performance.

Harnessing Trichoderma asperellum: Tri-Trophic Interactions for Enhanced Black Gram Growth and Root Rot Resilience.

Root rot caused by Macrophomina phaseolina, a common soil-borne disease in black gram, is managed with chemical fungicides, leading to toxicity and degradation of beneficial soil microbes. Existing bioagents, like talc formulation, cause leaching, clogging, and reduced productivity. The development of liquid bio-formulation via drip irrigation is crucial to mitigate biotic stress and maximize yield.

Ecological risk assessment and characterization of microplastics in the beach sediments of southeast coast of India.

This study explores spatiotemporal variations of microplastics (MPs) in beach sediments along India's southeast coast, focusing on Tamil Nadu and Puducherry from 2020 to 2021. The MPs were extracted from the sediments through density separation and wet peroxidation. Following extraction, they were quantified and physically characterized using stereo-microscopy and chemically analyzed using ATR-FTIR.

Extracellular vesicle mimetics engineered from mesenchymal stem cells and curcumin promote fibrosis regression in a mouse model of thioacetamide-induced liver fibrosis.

Recent research suggests that advanced liver fibrosis could be reversed, but the therapeutic agents needed for the prevention of liver fibrosis remain to be elucidated. The beneficial effects of mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (EVs) on liver fibrosis have been reported. However, the large-scale production of MSC-EVs remains challenging.