Publications by authors named "R Sampath"

Article Synopsis
  • The Rab40 subfamily consists of small GTPases that form a complex with CRL5, an E3 ligase, and are involved in the ubiquitylation of specific proteins, influencing cell migration.
  • Recent research has identified AMBRA1 as a new partner of Rab40, linking the functions of CRL4 and CRL5 E3 ligases, impacting gene transcription without leading to AMBRA1's degradation.
  • The study highlights that Rab40's ubiquitylation of AMBRA1 is crucial for regulating genes associated with cell adhesion and migration, indicating a significant role for the Rab40/CRL5 complex in these processes.
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This paper reviews the distinct clinical, pathophysiological, and therapeutic challenges faced by older women undergoing percutaneous coronary intervention (PCI). Older women present with a greater comorbidity burden, smaller coronary vessels, and post-menopausal hormonal changes, which increase procedural complexity and adverse cardiovascular outcomes. Despite these challenges, older women are less likely to receive evidence-based therapies, resulting in higher risks of major adverse cardiovascular events (MACE) and bleeding.

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The COVID-19 pandemic has highlighted the need to upgrade systems for infectious disease surveillance and forecasting and modeling of the spread of infection, both of which inform evidence-based public health guidance and policies. Here, we discuss requirements for an effective surveillance system to support decision making during a pandemic, drawing on the lessons of COVID-19 in the U.S.

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Alzheimer's is a degenerative brain cell disease that affects around 5.8 million people globally. The progressive neurodegenerative disease known as Alzheimer's Disease (AD), affects the frontal cortex, the part of the brain in charge of memory, language, and cognition.

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Secondary organizing pneumonia (SOP) as a sequela to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually has a prolonged benign course with a good response to corticosteroids. We present a case series of three patients who developed rapid progression to organizing pneumonia, after initial presentation with SARS-CoV-2. Imaging revealed rapid interval progression of bilateral subpleural ground glass opacities, and lung biopsy showed dense fibroblastic plugs within the alveoli.

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