Publications by authors named "R Salazar Mendez"
Article Synopsis
- Respiratory diseases and cardiovascular diseases (CVDs) often share common risk factors, like aging and smoking, and their relationship can impact the prognosis of each condition.
- The interactions between these diseases involve shared mechanisms such as inflammation, oxidative stress, and microvascular dysfunction, which can exacerbate both respiratory and cardiovascular issues.
- Understanding the coexistence of these diseases is crucial for adjusting treatment plans and improving overall patient outcomes.
Introduction: The Spanish Society of Pulmonology and Thoracic Surgery created a registry for hospitalised patients with COVID-19 and the different types of respiratory support used (RECOVID). Objectives. To describe the profile of hospitalised patients with COVID-19, comorbidities, respiratory support treatments and setting.
View Article and Find Full Text PDFThe development of highly potent and selective μ opioid receptor (MOR) modulators with favorable drug-like properties has always been a focus in the opioid domain. Our previous efforts led to the discovery of a lead compound designated as NAT, a potent centrally acting MOR modulator. However, the fact that NAT precipitated considerable withdrawal effects at higher doses largely impaired its further development.
View Article and Find Full Text PDFArticle Synopsis
- - Alternative splicing includes microexons in neuronal proteins, which are often linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
- - A specific 24-nucleotide microexon in the RNA-binding protein CPEB4, previously shown to be less included in individuals with ASD, plays a critical role in regulating gene expression linked to neurodevelopment.
- - The study finds that this microexon helps maintain the flexible regulation of CPEB4 during neuronal activation by preventing its aggregation, allowing it to switch from repressing to activating translation of genes.
Article Synopsis
- Complications from community-acquired pneumonia (CAP), such as cardiovascular events and mortality, can arise both during the illness and afterward; this study explores the role of specific biomarkers related to endothelial damage compared to traditional inflammation markers.
- The research analyzed data from 515 patients, measuring various biomarkers at different time intervals (day 1, day 5, and day 30) to determine their relationship with ICU admission, cardiovascular events, and mortality.
- Findings indicated that endothelial damage biomarkers (CT-proET-1 and MR-proADM) were more strongly associated with negative outcomes than inflammation markers (CRP and PCT), with MR-proADM being the most effective at predicting complications in both the short and long term.