Background: By 2050 the number of Alzheimer's Disease (AD) patients is projected to exceed 150 million worldwide. AD is an incurable, insufficiently understood, and devastating neurodegenerative disease, with high patient heterogeneity in terms of progression, clinical manifestation (including neuropsychiatric symptoms, NPS) and, importantly, responsiveness to treatment options.[1] In the last 20 years, 98% of clinical trials for AD have failed, highlighting the urgent need to drastically change pre-clinical research to develop better predictors of drug safety and effectiveness.
View Article and Find Full Text PDFChem Asian J
January 2025
Chirality is a vital characteristic of molecules and crucial for biological functioning. Glycals are unsaturated chiral sugars that contain an enolic double bond within the ring structure and they introduce the chirality in the molecular scaffolds. Since their discovery and synthesis by Fischer and Zach in 1913, they have been used as a flexible chiral synthon for synthesising natural products and biologically significant molecules.
View Article and Find Full Text PDFObjectives: To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game.
Design: Prospective, observational, comparative study (Tremor study).
Setting: Leeds Teaching Hospitals NHS Trust, Leeds, UK, during a three week period in 2024.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Background: The present study examined EEG microstate alterations and their neural generators during resting state in children with ADHD to explore a potential state biomarker.
Methods: A total of seventy-six participants, thirty-eight each, combined type ADHD, and neurotypical children (NC) participated in the study. Five-minute resting (eyes open) 128 channel eeg data were acquired and two-minute clean EEG data were analyzed for microstates, its sources and connectivity in both the groups.