Integrating Model-Informed Drug Development With AI: A Synergistic Approach to Accelerating Pharmaceutical Innovation.

The pharmaceutical industry constantly strives to improve drug development processes to reduce costs, increase efficiencies, and enhance therapeutic outcomes for patients. Model-Informed Drug Development (MIDD) uses mathematical models to simulate intricate processes involved in drug absorption, distribution, metabolism, and excretion, as well as pharmacokinetics and pharmacodynamics. Artificial intelligence (AI), encompassing techniques such as machine learning, deep learning, and Generative AI, offers powerful tools and algorithms to efficiently identify meaningful patterns, correlations, and drug-target interactions from big data, enabling more accurate predictions and novel hypothesis generation.

A 23-Year-Old Man With Multilobar Consolidation.

A 23-year-old man presented to the ED with a history of respiratory distress, cough, and fever for 10 days. He was evaluated in the ED, where he received a diagnosis of pulmonary edema, secondary to mitral regurgitation with mitral valve prolapse syndrome. He was treated with antibiotics and diuretics and discharged to home.

Facile synthesis of reduced graphene oxide/carbon/calcium alginate aerogel for the removal of pharmaceutical pollutants.

Pharmaceuticals are the new emerging challenge pollutants to removal from the aquatic environments. In this study, a series of reduced graphene oxide/carbon/calcium alginate (rGO/C/CA) aerogel was fabricated using an environmentally friendly freeze-drying method. The surface properties including surface textures, elemental contents, crystal structures, and functional groups of rGO/C/CA aerogel were investigated.

Tele-Manipulative Neuro-Registration in Robot assisted Neurosurgery.

This paper deals with neuro-registration using tele-manipulation (Master-Slave Manipulation) to facilitate tele-surgery and enhance the overall accuracy and reach of the robot-assisted neurosurgery. Accurate Neuro-registration is important as the success of the surgical procedure highly depends on it. A 6-degree-of-freedom Parallel Kinematic Mechanism (6D-PKM) master-slave robot in tele-manipulation mode is utilized for both neuro-registration and neurosurgery.

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling.

Purpose: Sulfur mustard gas (SM) exposure to eyes causes multiple corneal injuries including stromal cell loss in vivo. However, mechanisms mediating stromal cell loss/death remains elusive. This study sought to test the novel hypothesis that SM-induced toxicity to human corneal stromal fibroblasts involves ferroptosis mechanism via p38 MAPK signaling.