Recent Development, Applications, and Patents of Artificial Intelligence in Drug Design and Development.

Drug design and development are crucial areas of study for chemists and pharmaceutical companies. Nevertheless, the significant expenses, lengthy process, inaccurate delivery, and limited effectiveness present obstacles and barriers that affect the development and exploration of new drugs. Moreover, big and complex datasets from clinical trials, genomics, proteomics, and microarray data also disrupt the drug discovery approach.

Exploring Biophysical and Chemoinformatics Approaches for Interactions of Ionic Liquids With Hemoglobin, DNA, BSA, and HSA.

This review article provides an inclusive overview of the intricate interactions amid ionic liquids (ILs) and essential biomacromolecules, mainly hemoglobin (Hb), bovine serum albumin (BSA), human serum albumin (HSA), and calf thymus-DNA (CT-DNA). ILs have recently become a topic of great attention because of their inimitable physicochemical properties and potential uses in different fields. The review systematically explores the binding mechanisms, thermodynamics, and structural changes induced by ILs on Hb, BSA, HSA, and CT-DNA using spectroscopic, thermodynamic, and computational techniques.

Novel ionic liquid-infused PVA-based anion exchange membranes boosting bioelectricity yield from microbial fuel cells.

The goal of this research is to develop and characterize low-cost NHI doped polyvinyl alcohol (PVA)-4-ethyl-4-methylmorpholiniumbromide (ionic liquid) anion exchange membranes (AEM) and its application for membrane cathode assembly. Physical characterization like FTIR, POM, and XRD notified the functional groups, basic structure, and amorphosity of the produced membrane, and it was employed in single-chambered microbial fuel cells (sMFCs) as a separator. The membranes in terms of oxygen diffusion, proton conductivity, and ion exchange capabilities were evaluated.

Mutations in histones dysregulate copper homeostasis leading to defect in Sec61-dependent protein translocation mechanism in Saccharomyces cerevisiae.

The translocation of proteins from the cytoplasm to the endoplasmic reticulum occurs via a conserved Sec61 protein channel. Previously, we reported that mutations in histones cause downregulation of a CUP1 copper metallothionein, and copper exposure inhibits the activity of Sec61. However, the role of epigenetic dysregulation on the activity of channel is not clear.