Publications by authors named "R S Swenson"
B7-H3, an immunomodulatory protein overexpressed in many cancers, is associated with tumor aggressiveness and poor prognosis, making it a crucial target for imaging to elucidate its role in cancer progression and guide therapeutic interventions. This study employed PET imaging to investigate the in vivo delivery and pharmacokinetics of two anti-B7-H3 antibodies, Ab-1 and Ab-2, in mouse xenograft models with varying B7-H3 expression levels. The antibodies were radiolabeled with [Zr]Zr and evaluated through PET imaging, biodistribution studies, and in vitro assays to assess binding, tumor uptake, and retention.
View Article and Find Full Text PDFThe worldwide frequency of head and neck squamous cell carcinoma (HNSCC) is approximately 800,000 new cases, with 430,000 deaths annually. We determined that LZK (encoded by ) is a therapeutic target in HNSCC and showed that inhibition with small molecule inhibitors decreases the viability of HNSCC cells with amplified . A drug-resistant mutant of LZK blocks decreases in cell viability due to LZK inhibition, indicating on-target activity by two separate small molecules.
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- The study investigates the use of mini-fragment implants versus small-fragment implants for open reduction and internal fixation (ORIF) of ankle fractures, aiming to determine if mini-fragments lead to lower rates of elective implant removal and complications.
- It analyzed data from 505 patients, finding similar rates of elective implant removal (8.3% for mini-fragment vs. 10.8% for small-fragment) and complication rates (6.7% for mini-fragment vs. 6.5% for small-fragment).
- The authors conclude that while mini-fragment implants are popular, their higher cost must be weighed against their similar effectiveness to small-fragment implants in terms of implant removal and complications.
Article Synopsis
- Peptides are crucial for many biological processes, leading to increased interest in tracking their metabolism in living organisms.
- Dissolution-dynamic nuclear polarization (d-DNP) enhances nuclear magnetic resonance (NMR) sensitivity, allowing researchers to gather metabolic and physiological data in real-time.
- This study reveals the successful in vivo detection of metabolic changes in hyperpolarized C-oligopeptides, showing significant alterations in C-glutathione in mouse kidneys affected by acute kidney injury.
Article Synopsis
- Distal tibia shaft fractures often accompany posterior malleolar fractures (PMFs), leading to routine preoperative ankle CT scans to assess damage.
- A study analyzed data from 124 patients with these fractures, comparing outcomes between those who received CT scans and those who did not, but found no significant differences in key outcomes.
- While CT scans helped identify some PMFs that weren't visible on regular x-rays, they did not improve surgical efficiency or reduce complications related to PMFs.