[Effect of 3,12-B-dimethyloctahydroindolo-(2,3-a)-quinolyzine on the alcohol predilection of laboratory animals].

It was shown that 3,12-b-dimethyl-octahydroindol-(2,3-a) quinolyzine (at the dose of 1/6 of LD50) exerted an antialcohol effect in mice and rats which is probably due to an increased content of the brain 5-hydroxytryptamine resulting from selective inhibition of its deamination.

[Importance of initial monoamine oxidase activity to the development of the activating or inhibitory effect of N-methyl- and N-ethyloctahydronaphthoazepines].

Effect of N-methyl- and N-ethyl octahydronaphthazepines upon the MAO activity of brain mitochondria of intact rats and brain homogenates of the animals treated with iproniazid has been investigated in vitro. These compounds (0.1 mumole/ml) stimulated the deamination of noradrenaline in samples with low initial enzymatic activity and inhibited it in samples having high initial enzymatic activity.

[Importance of the initial monoamine oxidase activity for the development of the activating or inhibiting action of indolylhydrazides].

Effects of beta-(2-methyl indolyl-3) propionic acid hydrazide and alpha-butyl-beta-(2-methyl-5-carboxy indolyl-3) propionic acid hydrazide on the activity of monoamine oxidase were studied in rat brain in vitro. The compounds activated distinctly serotonin deamination under conditions of the enzyme inhibition, caused by pretreatment with iproniazide. The activation occurred only in the samples, which were not inhibited with iproniazide.

[Activating effect of indolylhdrazides on rat brain monamine oxidase].

Effects of hydrazide and isopropyl hydrazide of beta-/2-methyl indolyl-3/propionic acid as well as dihydrazide and isopropyl dihydrazide of alpha-butyl-beta/2-methyl-5-carboxyindolyl-3/propionic acid on activity of monoamine oxidase from rat brain were studied in vivo and in vitro. The effects of the preparations depend on the initial activity of the enzyme, concentrations of the compounds and on the substrate used. Decreased monoamine oxidase activity was the most suitable condition for detection of activating effect of compounds studied.