Publications by authors named "R S Rutkowski"
Objectives: The aim of the study was to create a Polish adaptation of the Highly Sensitive Person Scale (HSPS), assess its psychometric properties and conduct factor analysis in a group of adults.
Methods: Five hundred two students of the Poznan University of Medical Sciences, aged 19-40 were studied, assessed by the 27-item HSPS, Beck Depression Inventory (BDI) and NEO-FFI Questionnaire. Exploratory and confirmatory factor analysis was performed in two subgroups (N = 250 and N = 252, respectively).
Evolutionary Dynamics of Proinflammatory Caspases in Primates and Rodents.
Mol Biol Evol
December 2024
Caspase-1 and related proteases are key players in inflammation and innate immunity. Here, we characterize the evolutionary history of caspase-1 and its close relatives across 19 primates and 21 rodents, focusing on differences that may cause discrepancies between humans and animal studies. While caspase-1 has been retained in all these taxa, other members of the caspase-1 subfamily (caspase-4, caspase-5, caspase-11, and caspase-12 and CARD16, 17, and 18) each have unique evolutionary trajectories.
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- * Conducted on 30 RA patients and 20 healthy volunteers, the study found that RA patients had altered tryptophan metabolism, showing a decreased kynurenine-to-tryptophan ratio, indicating lower IDO activity.
- * Despite treatments leading to disease remission, no significant changes were observed in the kynurenine-to-tryptophan ratio after TNF-α inhibitor therapy, suggesting complex relationships between inflammation and tryptophan metabolism in RA.
Caspase-1 and related proteases are key players in inflammation and innate immunity. Here, we characterize the evolutionary history of caspase-1 and its close relatives across 19 primates and 21 rodents, focusing on differences that may cause discrepancies between humans and animal studies. While caspase-1 has been retained in all these taxa, other members of the caspase-1 subfamily (caspase-4, -5, -11, -12, and CARD16, 17, and 18) each have unique evolutionary trajectories.
View Article and Find Full Text PDFBackground: AGEs, their receptor (RAGE), and the extracellular newly identified receptor for AGEs product-binding protein (EN-RAGE) are implicated in the pathogenesis of inflammation.
Aim: We analyzed serum EN-RAGE, soluble RAGE (sRAGE), and their isoforms: endogenous secretory - esRAGE and cleaved - cRAGE concentrations in lean controls (n = 74) and in patients with obesity (n = 71) treated for three weeks with moderate calorie restriction (CR) combined with physical activity in a hospital condition.
Methods: Using the ELISA method, serum sRAGE, esRAGE, and EN-RAGE were measured before and after CR.