RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanisms and cellular responses remain poorly understood. In this work, we report that deficiency of ubiquitin-specific protease 39 (USP39) in human cell lines, zebrafish larvae, and mice led to impaired spliceosome assembly and a cytotoxic splicing profile characterized by the use of cryptic 5' splice sites.
View Article and Find Full Text PDFWhile the proliferation of the Internet of Things (IoT) has revolutionized several industries, it has also created severe data security concerns. The security of these network devices and the dependability of IoT networks depend on efficient threat detection. Device heterogeneity, computing resource constraints, and the ever-changing nature of cyber threats are a few of the obstacles that make detecting cyber threats in IoT systems difficult.
View Article and Find Full Text PDFA class of intricate musculoskeletal diseases known as temporomandibular disorders (TMDs) affects the temporomandibular joint (TMJ) and its supporting structures. The majority of individuals will at some point in their lives experience some degree of TMD symptoms, as these diseases are highly prevalent in the general population. TMDs are multifactorial and are attributed to various physical and biopsychosocial factors.
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