Publications by authors named "R S Ranganathan"
Nanoparticles have been of significant interest in various biomedical domains such as drug delivery, gene delivery, cytotoxicity analysis, and imaging. Despite the synthesis of a variety of nanoparticles, their cellular uptake efficiency remains a substantial obstacle, with only a small fraction of delivered nanoparticles (NPs) have been reported to traverse the cell membrane within 24 h. Consequently, higher doses are often necessitated, leading to increased toxicity concerns.
View Article and Find Full Text PDFCraniosynostosis-4 with Heterozygous Mutation in the Gene: A Case Report.
Int J Clin Pediatr Dent
October 2024
Article Synopsis
- Craniosynostosis (CS) is a condition where cranial sutures fuse prematurely, affecting 1 in 2,000-2,500 children, and can be categorized as syndromic or nonsyndromic based on the affected sutures.
- An 8-year-old girl displayed signs of CS, and genetic testing identified a mutation linked to craniosynostosis-4, while her dental evaluation revealed unerupted teeth and cavities.
- Treatment involved addressing dental issues, and the significance of CS includes its genetic basis, often involving new mutations, with associated complications like facial changes and developmental delays.
Article Synopsis
- The text discusses a new framework called BioM3 that allows for the design of proteins using natural language prompts, integrating text and protein representation in a novel way.
- This framework operates in three stages: aligning protein and text representations, refining text embeddings, and generating protein sequences using a specific model.
- BioM3 has shown impressive results in various protein-related tasks and successfully generates proteins with characteristics similar to naturally occurring ones, validated through experimental tests.
Background: The ability to relearn a lost skill is critical to motor recovery after a stroke. Previous studies indicate that stroke typically affects the processes underlying motor control and execution but not the learning of those skills. However, these studies could be confounded by the presence of significant motor impairments.
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