The landscape of chemokine and cytokine is associated with the distinct clinical status of leprosy patients and their respective household contacts.

Introduction: Leprosy, a chronic infectious disease, is closely linked to the host immune response. According to the WHO, leprosy patients (L) and household contacts (HHC) are classified into subgroups: paucibacillary (PB) and multibacillary (MB), witch reflect the degree of infection in patients and the level of exposure of their contacts. The main goal of this study was to: i) establish a comprehensive overview of soluble mediator signatures of PBMCs upon antigen-specific stimuli and ii) identify whether the chemokine (CH) and cytokine (CY) signatures were associated with distinct clinical manifestations in (L) and immune response profiles in (HHC).

Recommendations of the Brazilian Society of Surgical Oncology for the Treatment of Neoplastic Pericardial Effusion.

This document presents guidelines to assist surgeons in the diagnosis and management of this condition, emphasizing a multidisciplinary approach. Recommendations described by a group of physicians members of the Brazilian Society of Oncological Surgery regarding the treatment of neoplastic pericardial effusion, developed to guide oncological surgeons, cardiothoracic surgeons and general surgeons in their clinical practice. Members of the Thoracic Neoplasms Committee carried out a literature review and discussion among expert peers to create a guideline that would help in managing this very serious clinical condition in our oncology practice: Neoplastic pericardial effusion.

TREATMENT OF GASTRIC CANCER ACCORDING TO THE COMPLEXITY OF THE HOSPITAL ONCOLOGY UNIT: ANALYSIS OF 33,774 PATIENTS OVER TWO DECADES.

Background: The hospitals' volume, specialization, availability of all oncological services, and experience in performing complex surgeries have a favorable impact on gastric cancer (GC) treatment.

Aims: The aim of this study was to compare the results of GC treatment according to the type of oncological hospital in the State of São Paulo.

Methods: Patients diagnosed with GC between 2000 and 2022 in qualified hospitals for cancer treatment were evaluated by data extracted from the hospital cancer registry.

Structured lipids from fish viscera and coconut oils improve weight gain and intestinal morphology of piglets at nursery phase.

Five metabolism assays were performed to determine the metabolizable energy (ME) content of soybean oil, coconut oil, fish viscera oil, physical mixture of coconut oil and fish viscera oil (3:2, in kg: kg) and structured lipid prepared from interesterification of fish viscera oil and coconut oil (3: 2, in kg: kg), and one assay to evaluate the effects of including these lipid sources in piglet diets on performance, digestibility of diets, incidence of diarrhea and intestinal morphometry at nursery phase. Soybean, coconut, fish viscera, physical mixture and structured lipid oils showed ME values of 8239, 8199, 8839, 8268 and 8523 kcal/kg DM respectively. In the performance trial, a total of 90 piglets with 23 days of age were distributed among 5 diets, differing in the lipid source used (soybean oil, coconut oil, fish viscera oil, physical mixture or structured lipid).

Herbicides and bio-inputs: Compatibility and challenges for sustainable agriculture.

With population growth and the contamination of ecosystems by pesticides and chemical fertilisers, agriculture faces the challenge of increasing productivity in a sustainable manner. In response to this demand, the global ecological transition has promoted the use of bio-inputs, such as fungi and bacteria, which are essential for agricultural sustainability. However, the extensive use of herbicides in modern agriculture may compromise the effectiveness of these bio-inputs by interfering with their biochemical pathways.