Publications by authors named "R S Oosting"
Various models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs.
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- Despite extensive research, the exact cause of Alzheimer's disease (AD) is still unknown, leading to a new hypothesis focusing on the enzyme carnitine palmitoyl transferase-2 (CPT2) as a key player in the disease.
- CPT2, found in the inner mitochondrial membrane, is vital for fatty acid metabolism and is particularly sensitive to hydrogen peroxide, which is produced in excess by major AD risk factors.
- The inhibition of CPT2 due to increased hydrogen peroxide levels may contribute to the symptoms of AD, offering new insights for potential therapeutic strategies.
We report on a case of a 35-year-old man who died suddenly and unexpectedly due to a 4-fluoroisobutyrylfentanyl (4-FIBF) mono-intoxication. Pathological, toxicological and chemical investigations were conducted at the Netherlands Forensic Institute. A full three-cavity forensic pathological examination was performed according to international guidelines.
View Article and Find Full Text PDFObjective: Adolescent depression is a heterogeneous disorder, with a wide variety of symptoms and inconsistent treatment response, and is not completely understood. A dysregulated stress system is a consistent finding, however, and exhaustion is a consistent trait in adolescent patients. The aim of this paper is to critically assess current hypotheses in adolescent depression research and reframe causes and treatment approaches.
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