Potential of carnuba wax in ameliorating brittle fracture during tableting.

Carnuba wax (as binder) forms hard tablets even at low compression load attributable to its high plasticity. The aim of the present study is to investigate its potential in ameliorating brittle fracture (i.e.

A comparative study of dissolution characteristics of polymeric and wax granulations of theophylline and their tablets.

Matrix (non disintegrating) granules of theophylline have been formed and their dissolution characteristics investigated for sustained release application. The polymeric granulations were formed by massing the drug powder with a concentrated (40% w/w) ethanolic solution of an acrylatemethacrylate copolymer (ERS100R). Wax granulations were also formed by massing the drug powder with previously melted carnuba wax followed by screening and drying.

Multi-unit dosage formulations of theophylline for controlled release applications.

The study was carried out to investigate the drug release profiles of multi-unit dosage formulations of theophylline consisting of both the fast and slow release components in a unit dose. The fast release component consisted of conventional granules of theophylline formed by mixing the drug powder with starch mucilage (20% w/v) while the slow release component consisted of wax granulations of theophylline formed by triturating the drug powder with a melted Carnauba wax (drug:wax ratio, 4:1). The granules were either filled into capsules or tabletted.

A comparative study of the dissolution characteristics of capsule and tablet dosage forms of melt granulations of paracetamol--diluent effects.

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melted carnauba wax. The matrix granules were admixed with diluents (lactose, alpha-cellulose or microcrystalline cellulose) also in granular form to prevent size separation during encapsulation or tableting.

Studies on the compressibility of wax matrix granules of acetaminophen and their admixtures with various tableting bases.

Matrix granules of acetaminophen have been formed by a melt granulation process whereby the acetaminophen powder was triturated with the melted wax--goat wax, glyceryl monostearate or carnuba wax. The compressibility of the matrix granules and their admixture, with diluent granules (lactose, alpha-cellulose or microcrystalline cellulose) was investigated. The granules were compressed to tablets at a constant load (30 arbitrary units on the load scale) of a manesty single punch machine.