Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial.

Background: Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in major depressive disorder (MDD). However, the long-term effects of PT have never been compared with gold-standard treatments for MDD such as pharmacotherapy or psychotherapy alone or in combination.

Methods: This is a 6-month follow-up study of a phase 2, double-blind, randomised, controlled trial involving patients with moderate-to-severe MDD.

The Colorado Heart Failure Acuity Risk Model: A Mortality Model for Waitlisted Cardiac Transplant Patients.

Background: Currently, there is no mathematical model used nationally to determine the medical urgency of patients on the heart transplant waitlist in the United States. While the current organ distribution system accounts for many patient factors, a truly objective model is needed to more reliably stratify patients by their medical acuity.

Objectives: The aim of the study was to develop risk scores (Colorado Heart failure Acuity Risk Model [CHARM] score) to predict mortality in adults waitlisted for heart transplant.

Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction.

Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.

Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.

Factors influencing the healthcare programme selection of students in an Irish university.

Background: Globally, there is a rapidly increasing proportion of women studying and practising healthcare. This has been accompanied by a reducing proportion of males in most healthcare professions. This has been a contributory factor to the decreasing health staffing due to the tendency of females to work fewer hours and leave their profession earlier.

Geography, Trajectories, and Controls of Coastal Water Quality: More Rapid Improvement in the Shallow Zone of the Chesapeake Bay.

Many coastal ecosystems have suffered from cultural eutrophication and dead zones. In the Chesapeake Bay, water quality degradation is manifested in low dissolved oxygen, poor water clarity, and decreased submerged aquatic vegetation acreage. This research combines long-term monitoring data, science-based assessment methods, and novel data analysis approaches (i.