Publications by authors named "R S Mito"
Article Synopsis
- After a first seizure, anti-seizure medications (ASMs) can influence the likelihood of additional seizures, leading to a study that analyzes brain network changes using fMRI data from 28 participants before and during ASM therapy.
- The research found that ASM treatment increased the clustering coefficient and decreased network path length, indicating more efficient brain connections, with the greatest changes observed in specific brain regions linked to seizure activity.
- The findings suggest that individuals with recurrent seizures exhibit more significant network changes after ASM treatment, highlighting the need for larger studies to better understand the relationship between ASM effects and long-term seizure outcomes.
Article Synopsis
- White matter changes in temporal lobe epilepsy (TLE) are linked to cognitive impairments and possible neurodegenerative processes, with a study examining surgical resections from 44 patients.
- The research found increased arteriolosclerosis and alterations in microvascular structure, including reduced vessel size and higher pericyte coverage, particularly in deeper white matter, independent of age and linked to epilepsy duration.
- Additionally, there were significant changes in glial and myelin cell densities, with gene expression analysis indicating stronger myelination reductions in patients with hippocampal sclerosis, highlighting a relationship between imaging abnormalities and cognitive decline.
The tumor suppressor TP53 gene, the most frequently mutated gene in human cancers, produces the product tumor protein p53, which plays an essential role in DNA damage. p53 protein mutations may contribute to tumorigenesis by loss of tumor suppressive functions and malignancy of cancer cells via gain-of-oncogenic functions. We previously reported that mutant p53 proteins form aggregates and that cytoplasmic p53 aggregates were associated with poor prognosis in human ovarian cancer.
View Article and Find Full Text PDFBackground: Immunohistochemistry for p53 was a well-established method for cancer diagnosis in pathology. Aberrant cytoplasmic p53 positivity reflects the accumulation of p53 aggregates, which has been shown to be associated with chemoresistance and to be a predictive marker of a worse clinical course in ovarian cancer.
Case Report: A 65-year-old Japanese man was diagnosed with lung cancer, and surgical resection was performed.
Diffusion MRI has provided insight into the widespread structural connectivity changes that characterize epilepsies. Although syndrome-specific white matter abnormalities have been demonstrated, studies to date have predominantly relied on statistical comparisons between patient and control groups. For diffusion MRI techniques to be of clinical value, they should be able to detect white matter microstructural changes in individual patients.
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