Publications by authors named "R S Mangus"
This single-center retrospective study was designed to evaluate the use of basiliximab as an alternative rescue maintenance immunosuppression in situations where standard maintenance immunosuppression is not tolerated after a pancreas transplant. All pancreas transplants performed between January 11, 2006, and January 6, 2022, were reviewed. All recipients received rabbit antithymocyte globulin (rATG) induction with tacrolimus + sirolimus maintenance for simultaneous pancreas and kidney (SPK) and additional low-dose mycophenolic acid for pancreas transplant alone (PTA).
View Article and Find Full Text PDFBackground: Sarcopenia at the time of liver transplantation (LT) is an established risk factor for mortality following LT. However, most studies in this context have defined sarcopenia by one-time, static measurements. The aims of this study were (I) to determine the impact of the rate of muscle loss in waitlisted LT recipients on post-LT outcomes and (II) to identify patterns of serum metabolites associated with patients with more progressive sarcopenia.
View Article and Find Full Text PDFArticle Synopsis
- - MNGIE (mitochondrial neurogastrointestinal encephalopathy syndrome) is a rare genetic disorder caused by a deficiency in thymidine phosphorylase, leading to serious issues like gastrointestinal problems, muscle weakness, and neurological symptoms.
- - A case study highlights a 28-year-old man with MNGIE who underwent liver transplantation to improve his symptoms, but still faced ongoing gastrointestinal dysmotility and required nutritional support.
- - After extensive rehabilitation, he received an intestine transplant 2.5 years post-liver transplant, and four years later, he is off nutritional support and gradually improving, marking a significant milestone in treating this condition.
Background: Vascular thromboses (VT) are life-threatening events after pediatric liver transplantation (LT). Single-center studies have identified risk factors for intra-abdominal VT, but large-scale pediatric studies are lacking.
Methods: This multicenter retrospective cohort study of isolated pediatric LT recipients assessed pre- and perioperative variables to determine VT risk factors and anticoagulation-associated bleeding complications.